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Andrew R. Rahmberg William J. Neidermyer Jr. Matthew W. Breed Xavier Alvarez Cecily C. Midkiff Michael Piatak Jr. Jeffrey D. Lifson David T. Evans 《Journal of virology》2013,87(24):13917-13921
Here we show that simian immunodeficiency virus (SIV) infection of rhesus macaques results in rapid upregulation of tetherin (BST-2 or CD317) on peripheral blood lymphocytes, including the CD4+ CCR5+ T cell targets of virus infection, with a peak of induction that coincides with peak alpha interferon (IFN-α) levels in plasma, and that tetherin remains above baseline levels throughout chronic infection. These observations are consistent with a role for tetherin in innate immunity to immunodeficiency virus infection. 相似文献
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Consistent force-field calculations were performed on a series of methyl substituted pyrrolidones. Methyl substitution enhances the non-planarity of the pyrrolidone ring in a way wich varies with the position of the substituent. The effect of ring distortion is to produce skeletal contributions to the rotatory strength of the nπ* transition of the amide group. Depending on position of substitution, these reinforce or oppose the substituent contribution to optical activity. There is favorable agreement between the conformational calculations and the quadrant rule for the optical activity of the nπ* transition of the peptide chromophore. 相似文献
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The alkali-ion binding properties of two natural depsipeptide ion carriers, enniatin B (EnB) and valinomycin (VM), are examined and compared by the empirical force field method. While VM has been shown to bind preferentially K+, Rb+, and Cs+ over Na+ in most solvents, EnB is considerably less specific. We find that EnB forms two kinds of complexes, internal and external. In internal complexes, the ion binds to all six carbonyl oxygens, while in external ones, only three oxygens, preferentially those of the D-hydroxy-isovaleryl residues, are bound. The size of the internal cavity is best suited for Na+, while K+ and Rb+ squeeze in asymmetrically by distorting the molecule, and Cs+ not at all. External binding is much less specific. Since internal complexes possess much higher strain energies than external ones, the latter may be at least as stable as the former, even in fairly non-polar solvents. VM is calculated to bind only internally, and with much less strain energy than EnB. The size of its internal cavity is well suited for binding the ions K+, Rb+, and Cs+, but is too big for Na+. The difference between the binding energies of Na+ and K+ is much smaller than that between the corresponding hydration enthalpies, thus explaining the binding preference for the latter ion. 相似文献